Thermo Fisher Scientific KV1.2 (KCNA2) Polyclonal Antibody
Rabbit polyclonal antibody targeting KV1.2 (KCNA2), validated for WB, IP, and neutralization assays. Recognizes rat Kv1.2 residues 325–375. Suitable for research use in ion channel and neuronal signaling studies. Supplied as liquid, unconjugated, store...
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunoprecipitation (IP) | 1:10–1:500 |
| Neutralization (Neu) | 50–200 molar excess |
Product Specifications
| Property | Description |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to rat Kv1.2 (within residues 325–375) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11153170 |
Product Specific Information
Suggested positive control: HEK293 cell lysate.
Target Information
Kcna2 encodes a voltage-gated potassium channel (KV) belonging to the 6-TM family of potassium channels, which also includes Ca²⁺-activated Slo (7-TM) and SK subfamilies. The alpha subunits form tetramers with a single pore-forming region. These channels regulate neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume.
Kcna2 contains six membrane-spanning domains with a shaker-type repeat in the fourth segment and is part of the delayed rectifier class, allowing efficient repolarization after action potentials. The gene is intronless and clustered with KCNA3 and KCNA10 on chromosome 1. Diseases associated with KCNA2 include Epileptic Encephalopathy (Early Infantile, 32) and Undetermined Early-Onset Epileptic Encephalopathy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(PA5-23011_KV1.2_KCNA2_P63142-1_Rabbit.svg 및 PA5-23011_KV1.2_KCNA2_P63142-1_Rabbit_PDP.jpeg 이미지 포함)
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