Thermo Fisher Scientific USP25 Monoclonal Antibody (OTI6H4), TrueMAB
USP25 단백질을 인식하는 단클론 항체로 Western Blot에 최적화됨. Human 시료 반응성, Mouse IgG1 아이소타입. 액상 형태이며 1 mg/mL 농도. PBS, BSA, 글리세롤 완충액에 보관되며 -20°C에서 안정적 저장 가능.
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Applications
- Western Blot (WB): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI6H4 |
| Immunogen | Full length human recombinant protein of human USP25 produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Target Information
Modification of target proteins by ubiquitin participates in a wide array of biological functions. Proteins destined for degradation or processing via the 26S proteasome are coupled to multiple copies of ubiquitin. Attachment of ubiquitin or ubiquitin-related molecules may also result in changes in subcellular distribution or modification of protein activity.
Deubiquitination is catalyzed by proteases called deubiquitinating enzymes, which fall into four distinct families:
- Ubiquitin C-terminal hydrolases
- Ubiquitin-specific processing proteases (USPs)
- OTU-domain ubiquitin-aldehyde-binding proteins
- Jab1/Pad1/MPN-domain-containing metallo-enzymes
Among these, USPs are the most widespread deubiquitinating enzymes across evolution. They release ubiquitin from conjugated proteins and contain conserved catalytic domains with Cys and His boxes, while divergent terminal extensions may function in substrate recognition, localization, and protein interactions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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