Thermo Fisher Scientific Ep-CAM/CD326 (Rat) Monoclonal Antibody (SPM534)
Rat Ep-CAM/CD326 단백질을 인식하는 Mouse IgG1 단일클론 항체로, Western blot, IHC, ICC/IF, Flow cytometry, IP에 사용 가능. 인간과 반응하지 않으며, 단백질 A/G로 정제된 액상 형태. 연구용으로만 사용.
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Thermo Fisher Scientific Ep-CAM/CD326 (Rat) Monoclonal Antibody (SPM534)
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:100–1:200 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:100–1:200 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| Flow Cytometry (Flow) | 5–10 µL / 10⁶ cells |
| Immunoprecipitation (IP) | 5–10 µL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | SPM534 |
| Immunogen | Rat small intestine cells |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Protein A/G |
| Storage Buffer | Tissue culture supernatant, pH 7.4 |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Does not react with Human.
Target Information
Ep-CAM (epithelial adhesion molecule, epithelial specific antigen, ESA) is a transmembrane glycoprotein expressed in epithelial cells with a molecular weight of approximately 40 kDa.
It functions as a calcium-independent cell adhesion molecule and influences cell cycle, proliferation, and metabolism by inducing proto-oncogene c-myc and cyclins A and E.
Ep-CAM-mediated adhesions negatively regulate cadherin-mediated adhesions, affecting epithelial differentiation and growth.
Overexpression of Ep-CAM is associated with enhanced epithelial proliferation and is highly expressed in human carcinomas, serving as a marker for epithelial lineage tumors.
Ep-CAM is expressed on the baso-lateral surface of most simple epithelia and many carcinoma types, and helps distinguish adenocarcinomas from pleural mesotheliomas.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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