Thermo Fisher Scientific MESDC2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human MESDC2 protein. Validated for Western blot and immunohistochemistry. Detects endogenous MESDC2 involved in Wnt signaling and LDL receptor folding. Supplied as unconjugated liquid, 1 mg/mL concentration, stored...
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:3,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human MESDC2 (Accession Q14696), corresponding to amino acid residues A34–H84 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2815951 |
Product Specific Information
Antibody detects endogenous levels of total MESDC2.
Target Information
MESDC2 is a chaperone assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs).
Acts as a modulator of the Wnt pathway through chaperoning the coreceptors LRP5 and LRP6 to the plasma membrane.
Essential for specification of embryonic polarity and mesoderm induction.
Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4.
May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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