Thermo Fisher Scientific SREBF1 Monoclonal Antibody (4C11)

Applications

Western Blot (WB)

• Tested Dilution: 1–5 µg/mL

ELISA

• Tested Dilution: 0.03 ng/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
VTQLFREHLL ERALNCVTQP NPSPGSADGD KEFSDALGYL QLLNSCSDAA GAPAYSFSIS SSMATTTGVD PVAKWWASLT AVVIHWLRRD EEAAERLCPL

Target Information

Sterol regulatory element-binding proteins (SREBPs) are transcription factors belonging to the basic helix-loop-helix leucine zipper family of DNA-binding proteins.
Three isoforms (SREBP-1a, SREBP-1c, and SREBP-2) have been identified in mammalian tissues, differing in structure, regulation, and function.
SREBP-1a and SREBP-1c are products of alternative promoter usage of the SREBP-1 gene, while SREBP-2 is transcribed from a separate gene.

SREBPs exist as 120 kDa inactive precursors in the endoplasmic reticulum (ER) membrane. Upon activation, they are translocated to the Golgi, where proteolytic cleavage produces a mature transcriptionally active fragment (60–78 kDa).
In liver and adipose tissues, SREBPs regulate lipid and cholesterol accumulation by inducing transcription of related genes.
SREBP-1 primarily regulates triglyceride synthesis, while SREBP-2 is more closely associated with cholesterol synthesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.