Thermo Fisher Scientific SRD5A1 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1–5 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF RKIIIPFLF

Target Information

Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, mainly expressed in skin, and type 2, mainly expressed in the prostate.
In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein expression and varying transcriptional and translational levels. It is expressed throughout the hair follicle, whereas 5alpha-Reductase 2 is limited to mesenchymal portions.
Additionally, 5alpha-Reductase 1 is predominantly expressed in human breast carcinoma and may contribute to local androgen production and actions, including inhibition of cancer cell proliferation in hormone-dependent breast carcinoma. The 5alpha-Reductase–3alpha-hydroxysteroid dehydrogenase complex is also found in the human brain, suggesting involvement in neuroactive steroid synthesis or neurotoxic steroid catabolism.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.