Thermo Fisher Scientific SRD5A1 Polyclonal Antibody, MaxPab
SRD5A1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며, 인간 시료에 반응. PBS buffer 형태의 액상 제품으로, 보존제가 포함되지 않으며 -20°C에서 보관. Affinity chromatography로 정제된 고품질 연구용 항체.
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Applications
- Western Blot (WB): 1–5 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | SRD5A1 (NP_001038.1, 1–259 a.a) full-length human protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MATATGVAEE RLLAALAYLQ CAVGCAVFAR NRQTNSVYGR HALPSHRLRV PARAAWVVQE LPSLALPLYQ YASESAPRLR SAPNCILLAM FLVHYGHRCL IYPFLMRGGK PMPLLACTMA IMFCTCNGYL QSRYLSHCAV YADDWVTDPR FLIGFGLWLT GMLINIHSDH ILRNLRKPGD TGYKIPRGGL FEYVTAANYF GEIMEWCGYA LASWSVQGAA FAFFTFCFLS GRAKEHHEWY LRKFEEYPKF RKIIIPFLF
Target Information
Steroid 5alpha-Reductase is an important enzyme in androgen physiology because it catalyzes the conversion of testosterone into the more potent 5alpha-dihydro-testosterone, which mediates androgen effects on target tissues. The enzyme exists as two isoforms: type 1, mainly expressed in skin, and type 2, mainly expressed in the prostate.
In cultured human skin cells, 5alpha-Reductase 1 shows heterogeneity of protein expression and varying transcriptional and translational levels. It is expressed throughout the hair follicle, whereas 5alpha-Reductase 2 is limited to mesenchymal portions.
Additionally, 5alpha-Reductase 1 is predominantly expressed in human breast carcinoma and may contribute to local androgen production and actions, including inhibition of cancer cell proliferation in hormone-dependent breast carcinoma. The 5alpha-Reductase–3alpha-hydroxysteroid dehydrogenase complex is also found in the human brain, suggesting involvement in neuroactive steroid synthesis or neurotoxic steroid catabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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