Thermo Fisher Scientific TP53BP2 Monoclonal Antibody (3F8)

Applications

Tested Dilution

Publications

Western Blot (WB)

1-5 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

3 µg/mL

-

ELISA (ELISA)

0.3 ng/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG2a, kappa

Class

Monoclonal

Type

Antibody

Clone

3F8

Immunogen

TP53BP2 (AAH58918, 511 a.a. approximately 610 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:53BP2,uniProtId:Q13625-1,ncbiNodeId:9606,antigenRange:511-610,antigenLength:1128,antigenImageFileName:H00007159-M01_53BP2_Q13625-1_House_mouse.svg,antigenImageFileNamePDP:H00007159-M01_53BP2_Q13625-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: PYFGQTNQPP SDIKPDGSSQ QLSTVVPSMG TKPKPAGQQP RVLLSPSIPS VGQDQTLSPG SKQESPPAAA VRPFTPQPSK DTLLPPFRKP QTVAASSIYS

Target Information

Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.