Thermo Fisher Scientific PLB1 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Positive test controls include:

• A-431
• U-87MG
• HL-60
• HT-29
• Mouse testis
• Mouse lung
• Mouse skeletal muscle
• Rat testis

The target is usually found in:

• Apical cell membrane
• Single-pass type I membrane protein

Immunogen sequence:
ARPNNSSDLP TSWRGLSWSI GGDGNLETHT TLPNILKKFN PYLLGFSTST WEGTAGLNVA AEGARARDMP AQAWDLVERM KNSPDINLEK DWKLVTLFIG VNDLCHYCEN PEAHLATEYV QHIQQALDIL SEELPRAFVN VVEVMELASL YQGQGGKCAM LAAQNNCTCL RHSQSSLEKQ ELKKVNWNLQ HGISSFSYWH QYTQREDFAV VVQPFFQNTL TPLNERGDTD LTFFSEDCFH FSDRGHAEMA IALWNNMLEP VGRKTTSNNF THSRAKLKCP SPESPYLYTL RNSRLLPDQA EEAPEV

Target Information

This gene encodes a membrane-associated phospholipase that displays lysophospholipase and phospholipase A2 activities through removal of sn-1 and sn-2 fatty acids of glycerophospholipids.
Additionally, it has lipase and retinyl ester hydrolase activities.
The encoded protein is highly conserved and includes:

• Large glycosylated extracellular domain with four tandem homologous domains
• Hydrophobic segment anchoring the enzyme to the membrane
• Short C-terminal cytoplasmic tail

This gene has been identified as a candidate rheumatoid arthritis risk gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.