Thermo Fisher Scientific ATP Citrate Lyase Polyclonal Antibody
Rabbit polyclonal antibody targeting human ATP Citrate Lyase (aa 430–480). Validated for WB and ICC/IF. Affinity-purified with >95% purity. Supplied as liquid, 1 mg/mL concentration. Ideal for research use in lipid and acetylcholine biosynthesis studies.
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- PA575209
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- pk
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 430–480 of Human ATP Citrate Lyase |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2718937 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum using epitope-specific immunogen. Purity is >95% (by SDS-PAGE).
Target Information
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (approximate molecular weight 440,000) composed of identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA, with concomitant hydrolysis of ATP to ADP and phosphate.
Acetyl-CoA produced serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate lyase may be involved in acetylcholine biosynthesis. Two transcript variants encoding distinct isoforms have been identified for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일: PA5-75209_ATP_Citrate_Lyase_P53396-1_Rabbit_PDP.jpeg)
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