Thermo Fisher Scientific PANK2 Polyclonal Antibody
PANK2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot, IHC, ICC/IF에 적합합니다. 인간 시료에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. CoA 생합성 조절 효소 연구 및 PKAN 관련 연구에 활용 가능합니다.
- 카탈로그번호
- PA552563
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:20–1:50 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human PANK2 (amino acids 306–411). Recombinant protein control fragment: RP-89756 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2645193 |
Product Specific Information
Immunogen sequence:
SLHTVFCATG GGAYKFEQDF LTIGDLQLCK LDELDCLIKG ILYIDSVGFN GRSQCYYFEN PADSEKCQKL PFDLKNPYPL LLVNIGSGVS ILAVYSKDNY KRVTGT
Highest antigen sequence identity:
- Mouse: 98%
- Rat: 98%
Target Information
Pantothenate kinase (PANK2) is a key regulatory enzyme in coenzyme A (CoA) biosynthesis, catalyzing the cytosolic phosphorylation of pantothenate (vitamin B5), N-pantothenoylcysteine, and pantetheine. CoA functions as a major acyl carrier, essential for intermediary and fatty acid metabolism.
Mutations in PANK2 cause pantothenate kinase-associated neurodegeneration (PKAN), formerly known as Hallervorden-Spatz syndrome (HSS)*—an autosomal recessive neurodegenerative disorder characterized by iron accumulation in the brain. PANK2 mutations are also linked to *hypoprebetalipoproteinemia, acanthocytosis, retinitis pigmentosa, and pallidal degeneration (HARP).
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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