Thermo Fisher Scientific HJURP Polyclonal Antibody
HJURP 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. IHC(P) 및 ICC/IF 실험에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. PBS 기반 저장용액 포함, 4°C 또는 -20°C에서 안정적으로 보관 가능합니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:200–1:500
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human HJURP (Product #RP-89719) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2642456 |
Product Specific Information
Immunogen sequence:
TPVVQMATLT YETPQGLRIW GGRLIKERNE GEIQDSSMKP ADRTDGSVQA AAWGPELPSH RTVLGADSKS GEVDATSDQE ESVAWALAPA VPQSPLKNEL RRKYLTQVDI LLQGAEYFEC AGNRAGRDVR V
Highest antigen sequence identity to orthologs:
- Mouse: 37%
- Rat: 43%
Target Information
Holliday junction recognition protein (HJURP) is a centromeric protein that plays a central role in the incorporation and maintenance of histone H3-like variant CENPA at centromeres. It acts as a specific chaperone for CENPA and is required for the incorporation of newly synthesized CENPA molecules into nucleosomes at replicated centromeres. HJURP prevents CENPA-H4 tetramerization and premature DNA binding by the CENPA-H4 tetramer. It directly binds to Holliday junctions.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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