Merck Anti-RPA2 p34 Antibody, clone RPA20 1-46

Anti-RPA2 p34 Antibody, clone RPA20 1-46

from mouse, clone RPA20, clone 1-46

RF-A protein 2, RP-A p32, RP-A p34, Replication factor A protein 2, replication protein A2 (32kD), replication protein A2, 32kDa, Replication protein A 32kDa subunit, RF-A, replication factor-A protein 2, p32, p34, RPA2, REPA2, RPA32.

Quality Level

100

생물학적 소스

mouse

항체 형태

affinity isolated antibody

antibody product type

primary antibodies

클론

1-46, monoclonal
RPA20, monoclonal

species reactivity

mouse, human

포장

antibody small pack of 25 μg

technique(s)

western blot: suitable

동형

IgG1κ

NCBI 수납 번호

NM_002946

UniProt 수납 번호

P15927

배송 상태

ambient

RPA is a heterotrimeric protein complex that binds specifically to single-stranded DNA (ssDNA). It is composed of three subunits, RPA1 (70 kDa), RPA2 (32 kDa), and RPA3 (14 kDa), and plays multiple roles in DNA metabolism. RPA is required for DNA replication initiation, as well as replication elongation. At the onset of DNA replication, RPA is loaded onto chromatin after the binding of Cdc45 to origins. RPA is needed for subsequent loading of DNA polymerase and other replication proteins to initiate DNA replication. After DNA replication begins, RPA moves with replication forks, stabilizing ssDNA and assisting in DNA synthesis. In addition to its replication function, RPA is also known to play essential roles in damage repair and recombination.The 32 kDa subunit, is phosphorylated by the cdc2 family of kinases when cells enter S-phase and in response to DNA damage by ATM, ATR, and DNA-PK. Alternate names for RPA32 include replication protein A 32 kDa subunit, RP-A, RF-A, replication factor-A protein 2, p32, p34, RPA2, REPA2, and RPA32.