Merck Anti-SIRT1 Antibody, clone 10E4

Anti-SIRT1 Antibody, clone 10E4

clone 10-E-4, from mouse

SIR2-like protein 1, sir2-like 1, sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae), sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1, sirtuin 1, sirtuin type 1

Quality Level

100

생물학적 소스

mouse

항체 형태

purified immunoglobulin

antibody product type

primary antibodies

클론

10-E-4, monoclonal

species reactivity

mouse, human

포장

antibody small pack of 25 μL

technique(s)

ChIP: suitable
immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI 수납 번호

NP_036370.2

UniProt 수납 번호

Q96EB6

배송 상태

ambient

Gene Information

human ... SIRT1(23411)

Sir2 is short for Silent mating type Information Regulation-2. Sir2 (whose homolog in mammals is known as SIRT1, SIR2L1 or Sir2α) is the namesake of a family of closely related enzymes, the sirtuins. Members of this family have been found in nearly all organisms studied. Sirtuins are hypothesized to play a key role in an organism′s response to stresses (such as heat or starvation) and to be responsible for the lifespan-extending effects of calorie restriction. Sirtuins act by removing acetyl groups from proteins in the presence of NAD+; they are thus classified as NAD+-dependent deacetylases. In mammals, SIRT1 (the mammalian homolog of Sir2) has been shown to deacetylate and thereby deactivate the p53 protein.