Merck Anti-β-Amyloid antibody, Mouse monoclonal
β-Amyloid 단백질을 인식하는 Mouse monoclonal 항체로, Alzheimer’s disease 연구에 적합. Western blot, IHC, ELISA, IP 등 다양한 분석에 사용 가능. Human 시료 반응성. 정제된 IgG2a 형태로 −20°C에서 보관.
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Anti-β-Amyloid antibody, Mouse monoclonal
Clone: NAB 228
Source: Mouse hybridoma cell culture
Type: Anti-Aβ, purified immunoglobulin
제품 개요
이 항체는 인간 β-amyloid 단백질을 인식하는 mouse monoclonal 항체로, Alzheimer’s disease 연구에서 β-amyloid 축적 및 분포 분석에 활용됩니다.
제품 사양
| 항목 | 내용 |
|---|---|
| Quality Level | 200 |
| Biological Source | Mouse |
| Conjugate | Unconjugated |
| Antibody Type | Primary antibody |
| Clone | NAB 228, monoclonal |
| Form | Buffered aqueous solution |
| Molecular Weight | Antigen ~110 kDa |
| Species Reactivity | Human |
| Packaging | 25 μL (small pack) |
| Concentration | ~2 mg/mL |
| Isotype | IgG2a |
| UniProt Accession No. | P05067 |
| Shipping | Dry ice |
| Storage Temperature | −20 °C |
적용 기술
- Immunohistochemistry: suitable
- Immunoprecipitation (IP): suitable
- Indirect ELISA: suitable
- Microarray: suitable
- Western blot: 2–4 μg/mL using cell extract of human embryonal carcinoma NTERA-2 (NT2/D1) cells treated 2–3 weeks with 10 μM retinoic acid
Gene Information
Human APP (351)
The β-amyloid precursor protein (APP) is cleaved sequentially by β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides, mainly Aβ1-42 and Aβ1-40. These peptides are degraded either via re-uptake and endosomal degradation or by extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to aggregate and fibril formation, resulting in amyloid deposits called neuritic plaques, a hallmark of Alzheimer’s disease.
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