Merck Anti-β-Amyloid antibody, Mouse monoclonal

Anti-β-Amyloid antibody, Mouse monoclonal

clone NAB 228, purified from hybridoma cell culture

Anti-Aβ

Quality Level

200

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified immunoglobulin

antibody product type

primary antibodies

클론

NAB 228, monoclonal

form

buffered aqueous solution

분자량

antigen ~110 kDa

species reactivity

human

포장

antibody small pack of 25 μL

농도

~2 mg/mL

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
microarray: suitable
western blot: 2-4 μg/mL using cell extract of the human embryonal carcinoma NTERA-2 (NT2/D1) cells, treated for 2-3 weeks with 10 μM retinoic acid

동형

IgG2a

UniProt 수납 번호

P05067

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... APP(351)

The β-amyloid precursor protein (APP) is cleaved sequentially by the proteolytic enzymes β-secretase (BACE1) and γ-secretase to produce β-amyloid (Aβ) peptides with the Aβ1-42 and the Aβ1-40 forms being the most prevalent. Secreted Aβ peptides are degraded either via a re-uptake mechanism followed by endosomal degradation, or by an extracellular insulin degrading enzyme. Extracellular accumulation of Aβ leads to the formation of aggregates, fibrils and eventually amyloid deposits called neuritic plaques, which is the hallmark of Alzheimer′s disease (AD).