Merck Anti-MAP2 (2a+2b) antibody, Mouse monoclonal

Anti-MAP2 (2a+2b) antibody, Mouse monoclonal

~2 mg/mL, clone AP-20, purified from hybridoma cell culture

Anti-MAP2 (2a+2b) antibody, Mouse monoclonal, Anti-Microtubule Associated Protein 2

Quality Level

200

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified from hybridoma cell culture

antibody product type

primary antibodies

클론

AP-20, monoclonal

form

buffered aqueous solution

분자량

apparent mol wt 280 kDa

species reactivity

Xenopus, bovine, human, mouse, rat, aquatic salamander, quail

포장

antibody small pack of 25 μL

농도

~2 mg/mL

technique(s)

immunocytochemistry: suitable
microarray: suitable
western blot: 1-3 μg/mL using rat brain preparation or rat cerebral cortex extract

동형

IgG1

UniProt 수납 번호

P11137

배송 상태

dry ice

저장 온도

−20°C

Gene Information

human ... MAP2(4133)
mouse ... Mtap2(17756)
rat ... Map2(25595)

MAP2 is the major microtubule associated protein of brain tissue. There are three forms of MAP2; two are similarily sized with apparent molecular weights of 280 kDa (MAP2a and MAP2b) and the third with a lower molecular weight of 70 kDa (MAP2c). In the newborn rat brain, MAP2b and MAP2c are present, while MAP2a is absent. Between postnatal days 10 and 20 MAP2a appears, at levels equal to that of MAP2b. At the same time, the level of MAP2c drops by 10-fold. This change happens during the period when dendrite growth is completed and when neurons have reached their mature morphology. MAP2 is degraded by a Cathepsin D like protease in the brain of aged rats. There is some indication that MAP2 is expressed at higher levels in some types of neurons than in others.