Merck PCSK9 murine

PCSK9 murine

recombinant, expressed in HEK 293 cells, ≥97% (SDS-PAGE)

Proprotein convertase subtilisin/kexin type 9, PC9, NARC-1, NARC1, FH3, HCHOLA3, LDLCQ1, PCSK9

생물학적 소스

mouse

재조합

expressed in HEK 293 cells

태그

6-His tagged (N-terminus)

assay

≥97% (SDS-PAGE)

form

lyophilized powder

분자량

calculated mol wt 72 kDa
observed mol wt 20 kDa (DTT-reduced. Protein migrates due to glycosylation. Gln 35 is the predicted N-terminus .)
observed mol wt 64 kDa

포장

pkg of 20 μg

불순물

<1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

Q80W65

배송 상태

wet ice

저장 온도

−20°C

Gene Information

mouse ... PCSK9(100102)

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).