Merck SILuLite CCL2 C-C motif chemokine 2 human

SILu™Lite CCL2 C-C motif chemokine 2 human

recombinant, expressed in HEK 293 cells, MS Protein Standard

Monocyte secretory protein JE, HC11, Monocytechemoattractantprotein1, Monocyte chemotactic protein 1(MCP-1), Small-inducible cytokine A2, Monocytechemotacticandactivatingfactor(MCAF), Monocyte chemoattractant protein 1

Quality Level

200

생물학적 소스

human

재조합

expressed in HEK 293 cells

assay

≥98% (SDS-PAGE)

form

lyophilized powder

효능

≥98% Heavy amino acids incorporation efficiency by MS

technique(s)

mass spectrometry (MS): suitable

적합성

suitable for mass spectrometry (internal calibrator)

UniProt 수납 번호

P13500

저장 온도

−20°C

Gene Information

human ... CCL2(6347)

CCL2, the most thoroughly characterized CC chemokine, is a monocyte-specific chemoattractant that was demonstrated to attract T lymphocytes and NK cells, but not neutrophils. Enhanced expression of CCL2 was demonstrated in a variety of pathologic conditions, associated with inflammation and mononuclear cell infiltration. Extensive experimental evidence suggests that CCL2 is highly expressed in atherosclerotic plaques. In a recent study, CCL2 was shown to have value as a biomarker for risk stratification in both the initial and the chronic phases after an acute coronary syndromes (ACS). In contrast to CRP, CCL2 levels may be an indicator of long-term cardiovascular risk rather than a marker of acute prognosis. In urine, CCL2 levels were directly associated to Systemic Lupus Erythematosus disease activity, making it a non-invasive biomarker (avoiding blood sampling or tissue biopsies).