Merck SILuLite COL1A1 N-terminal propeptide human

SILu™Lite COL1A1 N-terminal propeptide human

recombinant, expressed in HEK 293 cells, MS Protein Standard

Collagen alpha-1(I) chain, Collagenalpha-1(I)chain, P1NP

Quality Level

200

생물학적 소스

human

재조합

expressed in HEK 293 cells

assay

≥98% (SDS-PAGE)

form

lyophilized powder

효능

≥98% Heavy amino acids incorporation efficiency by MS

technique(s)

mass spectrometry (MS): suitable

적합성

suitable for mass spectrometry (internal calibrator)

UniProt 수납 번호

P02452

저장 온도

−20°C

Gene Information

human ... COL1A1(1277)

Collagen type I is present in soft connective tissues and bone, where it constitutes more than 90% of the organic matrix.1 During bone formation collagen type I is synthesized from pro-collagen type I, which is secreted from fibroblasts and osteoblasts.2 Pro-collagen type I contains N-and C-terminal extensions, which are removed by specific proteases during the conversion of procollagen to collagen.3 Measurements of N- terminal propeptides of procollagen type I (PINP) can be of value in assessing bone formation. Recent evidence indicates that PINP can serve as a serum biomarker of bone formation, as it accurately identifies those patients who are responding to anabolic or antiresorptive therapy within 3 months of the start of treatment.4 The use of this biomarker in patients being treated for osteoporosis may significantly improve therapy adherence and clinical outcomes.4