Merck SILuLite APOA1 Apolipoprotein A-1 human

SILu™Lite APOA1 Apolipoprotein A-1 human

recombinant, expressed in HEK 293 cells, MS Protein Standard

SILuLite Apolipoprotein A-1

Quality Level

200

생물학적 소스

human

재조합

expressed in HEK 293 cells

태그

His tagged
V5 tagged

assay

≥98% (SDS-PAGE)

form

lyophilized powder

포장

vial of 50-65 μg (Lot-specific vial content given on certificate of analysis)

technique(s)

mass spectrometry (MS): suitable

UniProt 수납 번호

P02647

저장 온도

−20°C

Gene Information

human ... APOA1(335)

Apolipoprotein A-1(Apo-A1), is a major protein component of high density lipoprotein (HDL)in plasma1. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters2. Apo-A1 was shown to assist in the improvement of predicting cardiovascular events3. The gene that encodes to Apolipoprotein A-1 is APOA1. This gene is closely linked with two other apolipoprotein genes on chromosome 114. Defects in this gene are associated with HDL deficiencies, including Tangier disease5, and with systemic non-neuropathic amyloidosis6. The protein is made up of one major isoform (pI 5.6) and two minor isoforms (pI 5.53 and 5.46). Apo-A1 shows a high content of a-helix structure6. The amphipathic regions in the α-helix structure seem to be responsible for lipid binding capacity. In aqueous solution, Apo-A1 shows self-association with minor conformational change7. In addition, it has been shown that Apo-A1 is implicated in the anti-endotoxin function of HDL via interaction with lipopolysaccharide or endotoxin8.