Merck ChIPAb+ Dimethyl-Histone H4 (Arg3) Symmetric - ChIP Validated Antibody and Primer Set

ChIPAb+ Dimethyl-Histone H4 (Arg3) Symmetric - ChIP Validated Antibody and Primer Set

생물학적 소스

rabbit

품질 등급

100 (M-Clarity Program)

클론

polyclonal

정제법

affinity chromatography

Species Reactivity

mouse, human, rat

제조사 / 상품명

ChIPAb+
Upstate®

적용 기술

• ChIP: suitable
• dot blot: suitable
• western blot: suitable

NCBI 수납 번호

NP_001029249

UniProt 수납 번호

P62805

배송 상태

dry ice

Histones are highly conserved proteins that serve as the structural scaffold for the organization of nuclear DNA into chromatin.
The four core histones, H2A, H2B, H3, and H4, assemble into an octamer (2 molecules of each).
Histones are modified post-translationally by the actions of enzymes in both the nucleus and cytoplasm.
These modifications—acetylation, phosphorylation, methylation, and ubiquitination—occur predominantly on the N-terminal and C-terminal tails extending beyond the nucleosome core particle.

Arginine modifications of histone proteins are mediated by two classes of protein arginine methyltransferases (PRMTs), class I and II.

• Class I PRMTs place two methyl groups on one nitrogen atom of the arginine guanidino group, resulting in asymmetric modification.
• Class II PRMTs place two methyl groups on two nitrogen atoms of the guanidino group, producing symmetric dimethylation.

Although exceptions exist, asymmetric modifications are typically associated with transcription activation, while symmetric modifications are most commonly linked to transcriptional repression.