Merck ChIPAb+ Sp1 - ChIP Validated Antibody and Primer Set

ChIPAb+ Sp1 - ChIP Validated Antibody and Primer Set

from rabbit

Transcription factor Sp1, TSFP1

생물학적 소스

rabbit

Quality Level

100

클론

polyclonal

species reactivity

human, mouse, rat

manufacturer/tradename

ChIPAb+
Upstate®

technique(s)

ChIP: suitable
western blot: suitable

NCBI 수납 번호

NM_138473.2

UniProt 수납 번호

P08047

배송 상태

dry ice

Transcription factor SP1 can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression. Isoform 3 is a stronger activator of transcription than isoform 1. Positively regulates the transcription of the core clock component ARNTL/BMAL1.