Merck IL-24 human

IL-24 human

recombinant, expressed in Saccharomyces cerevisiae, ≥98% (SDS-PAGE), ≥98% (HPLC)

ST16, MDA7, IL10B, FISP, IL-24, C49A

생물학적 소스

human

재조합

expressed in Saccharomyces cerevisiae

assay

≥98% (HPLC)
≥98% (SDS-PAGE)

form

lyophilized

분자량

~19.5 kDa

포장

pkg of 10 μg

불순물

endotoxin, tested

NCBI 수납 번호

Q13007

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... IL24(11009)

IL24 is a member of the IL10 family of cytokines. It was identified as a gene induced during terminal differentiation in melanoma cells. IL-10B encoded can induce apoptosis selectively in various cancer cells. Overexpression IL-24 leads to elevated expression of several GADD family genes, which correlates with the induction of apoptosis. The phosphorylation of mitogen-activated protein kinase 14 (MAPK7/P38), and heat shock 27kDa protein 1 (HSPB2/HSP27) are found to be induced by this gene in melanoma cells, but not in normal immortal melanocytes. Alternatively spliced transcript variants encoding distinct isoforms have been reported. The glycosylation is essential for activity of IL-24. Functionally, IL-24 has diverse activities. At low concentrations, it induces type I proinflammatory cytokines such as IFN-γ, IL-1β, IL-12 and TNF-α. At high concentration, it is a strong inducer of apoptosis in tumor cells, but not normal cells. mda-7/IL-24 is being hailed as a ‘magic bullet′ for cancer gene therapy. Recombinant human Il-24 produced in yeast is a single, glycosylated, polypeptide chain containing 158 amino acids and having a molecular mass of 18 kDa. As a result of glycosilation, the protein migrates at 19.5 kDa on SDS-PAGE.