Merck PTEN human

PTEN human

recombinant, expressed in E. coli

Phosphatidylinositol-3, PTEN, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog

생물학적 소스

human

재조합

expressed in E. coli

assay

≥90%

form

liquid

분자량

~86.0 kDa

포장

pkg of 5 μg

저장 조건

avoid repeated freeze/thaw cycles

불순물

<0.1 EU/μg

NCBI 수납 번호

P60484

배송 상태

dry ice

저장 온도

−70°C

Gene Information

human ... PTEN(5728)

PTEN, a tumor suppressor, has been implicated in a large number of human tumors and is conserved from humans to worms. Characterization of PTEN protein showed that it is a phosphatase that acts on proteins and on 3-phosphorylated phosphoinositides, and can therefore modulate signal-transduction pathways that involve lipid second messengers. Recent results indicate that at least part of its role is to regulate the activity of the serine/threonine kinase AKT/PKB, and thus influence cell survival signaling. Recombinant PTEN is purified by proprietary chromatographic techniques.