Merck sRANK Ligand from rat

sRANK Ligand from rat

recombinant, expressed in E. coli, ≥98% (SDS-PAGE)

TRANCE Receptor, ODAR (osteoclast differentiation and activation receptor), ODFR (osteoclast differentiation factor receptor), TNFRSF11A

생물학적 소스

rat

재조합

expressed in E. coli

assay

≥98% (SDS-PAGE)

form

lyophilized powder

분자량

19.4 kDa

포장

pkg of 10 μg
pkg of 50 μg

불순물

<1 EU/μg endotoxin (LAL test)

UniProt 수납 번호

O00300

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... TNFRSF11(4982)

RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naïve T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cell-mediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansive osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.3 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (175 amino acid residues).