Merck Epidermal Growth Factor Receptor human

Epidermal Growth Factor Receptor human

buffered aqueous glycerol solution, 5,000-30,000 units/mg protein (Lowry)

EGFR

Quality Level

300

생물학적 소스

human

form

buffered aqueous glycerol solution

효능

5000.00-30000.00 units/mg

specific activity

5,000-30,000 units/mg protein (Lowry)

분자량

~170 kDa

포장

pkg of 500UN

저장 조건

avoid repeated freeze/thaw cycles

색상

colorless

UniProt 수납 번호

P00533

배송 상태

dry ice

저장 온도

−70°C

Gene Information

human ... EGFR(1956)

Affinity purified from human carcinoma A431 cells.
Epidermal growth factor receptor (EGFR) belongs to a family of cell surface receptors called receptor tyrosine kinases (RTKs), and is also the most studied member of this family. It is made up of an ectodomain (ECD), which contains four subdomains called DI-DIV, a transmembrane region, and a cytoplasmic tyrosine kinase domain (TKD). Binding of the ligand induces conformational changes in the ECD, which leads to the dimerization of EGFR. This results in the activation of the TKD, and the subsequent signal transduction. This receptor has a molecular weight of ∼178kDa.