Merck WNT-7A human

WNT-7A human

recombinant, expressed in HEK 293 cells, ≥80% (SDS-PAGE), ≥80% (HPLC)

생물학적 소스

human

재조합

expressed in HEK 293 cells

assay

≥80% (HPLC)
≥80% (SDS-PAGE)

form

lyophilized

효능

40-60 ng/mL ED50

분자량

35.5 kDa

포장

pkg of 15 μg

불순물

<0.1 EU/μg endotoxin, tested

색상

white

UniProt 수납 번호

O00755

배송 상태

wet ice

저장 온도

−20°C

Gene Information

human ... WNT7A(7476)

Wnt-7a is expressed in placenta, kidney, testis, uterus, fetal lung and fetal and adult brain. Most Wnt proteins can signal though a mechanism called the canonical Wnt pathway, in which Wnt proteins bind to and activate seven-pass transmembrane receptors of the Frizzled family ultimately leading to the disruption of β-Catenein degradation. Intracellular accumulation of β-Catenin increases translocation of the protein into the nucleus where it binds to TCF/LEF transcription factors and induces the expression of numerous genes. Increased Wnt/β-Catenein signaling is associated with tumorigenesis in a diverse set of human cancers. However, Wnt-7a/Frizzled-9 signaling has been shown to act as a tumor suppressor in non-small cell lung cancers.