Merck Brain-derived neurotrophic factor human

Brain-derived neurotrophic factor human

BDNF, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

BDNF, Abrineurin

Quality Level

200

생물학적 소스

human

재조합

expressed in E. coli

assay

≥95% (SDS-PAGE)

form

lyophilized powder

효능

≤15 ng/mL ED50

품질

endotoxin tested

분자량

~ 27 kDa

포장

pkg of 10 μg
pkg of 5 μg

저장 조건

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

불순물

≤1.00 EU/μg Endotoxin level

UniProt 수납 번호

P23560

저장 온도

−20°C

Gene Information

human ... BDNF(627) , BDNF(627)

BDNF is a member of the neurotrophin family of growth factors that includes NGF, NT-3, and NT-4. All neurotrophins have six conserved cysteine residues and share a 55% sequence identity at the amino acid level. BDNF has been shown to enhance the survival and differentiation of several classes of neurons in vitro, including neural crest and placode-derived sensory neurons, dopaminergic neurons in the substantia nigra, basal forebrain cholinergic neurons, hippocampal neurons, and retinal ganglial cells.1 BDNF is expressed within peripheral ganglia and is not restricted to neuronal target fields, raising the possibility that BDNF has paracrine or even autocrine actions on neurons as well as non-neuronal cells.
The active form of BDNF recombinant human protein (27 kDa) is a dimer formed by two identical 119 amino acid subunits held together by strong hydrophobic interactions