Thermo Fisher Scientific HLA-DMB Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.

Target Information

HLA-DMB (major histocompatibility complex, class II, DM beta), also known as D6S221E, RING7, HLA-DM histocompatibility type beta chain, HLADMB or RING7, is a protein encoded by the HLA-DMB gene located on chromosome 6p21.32.
HLA-DMB belongs to the HLA class II beta chain paralogues and forms a heterodimer with the alpha (DMA) chain, both anchored in the membrane and located in intracellular vesicles.
DM plays a central role in peptide loading of MHC class II molecules by releasing the CLIP (class II-associated invariant chain peptide) molecule from the peptide binding site.
Class II molecules are expressed in antigen-presenting cells. The beta chain is approximately 26–28 kDa and its gene contains 6 exons.
HLA-DMA and -DMB encode subunits of a functional heterodimer critical for class II antigen presentation.
HLA and MHC antibodies are key tools in Immunopeptidomics, aiding identification and characterization of neoantigens via LC–MS/MS.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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