Thermo Fisher Scientific IL1F6 Monoclonal Antibody (OTI1A4), TrueMAB

Thermo Fisher Scientific IL1F6 Monoclonal Antibody (OTI1A4), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

The IL-1 family consists of 11 structurally related ligands, including IL-36α (IL-1F6), IL-36β (IL-1F8), and IL-36γ (IL-1F9). IL-36α is highly expressed in psoriatic plaques and uniquely expressed by T cells, monocytes, and B cells. It is primarily found in skin and lymphoid tissues, with lower expression in fetal brain, trachea, stomach, and intestine.
IL-36α signals through IL-1Rrp2 (IL-1R6) and IL-RAcP receptors, acting as an agonist of NF-κB and MAPK pathways, and induces proinflammatory cytokines and chemokines such as IL-6, IL-8, BD-2, and BD-3.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.