Thermo Fisher Scientific TPSG1 Monoclonal Antibody (OTI4E1), TrueMAB
인간 TPSG1 단백질(아미노산 20-283)에 특이적인 Mouse IgG1 단일클론 항체. Western blot에 1:200 희석으로 검증됨. 액상 형태로 0.98 mg/mL 농도, PBS/BSA/glycerol buffer에 보존. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB)
Tested Dilution: 1:200
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4E1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 20–283 of human TPSG1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.98 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Tryptase gamma, also known as serine protease 31 or transmembrane tryptase, is an enzyme encoded by the TPSG1 gene in humans. Tryptases belong to the family of trypsin-like serine proteases (peptidase family S1). They are enzymatically active only as heparin-stabilized tetramers and resistant to known endogenous proteinase inhibitors.
Several tryptase genes are clustered on chromosome 16p13.3, with four functional genes identified: alpha I, beta I, beta II, and gamma I. Each has allelic variants (e.g., alpha II, beta III, gamma II). Beta tryptases are mainly expressed in mast cells, while alpha-tryptases predominate in basophils. TPSG1 differs from other family members by having a C-terminal hydrophobic domain that may act as a membrane anchor. Tryptases are implicated as mediators in asthma and other allergic or inflammatory disorders.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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