Thermo Fisher Scientific NMT2 Monoclonal Antibody (OTI1G3), TrueMAB

Thermo Fisher Scientific NMT2 Monoclonal Antibody (OTI1G3), TrueMAB

Applications and Tested Dilution

Product Specifications

Target Information

Proteolytic degradation is critical to maintaining appropriate levels of short-lived and regulatory proteins involved in cellular metabolism, heat shock and stress response, antigen presentation, modulation of cell surface receptors and ion channels, cell cycle regulation, transcription, and signaling factors.
The ubiquitin-proteasome pathway deconstructs most proteins in the eukaryotic cell cytosol and nucleus, while others are degraded via the vacuolar pathway involving endosomes, lysosomes, and the endoplasmic reticulum.
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine (~2.5 MDa) composed of a 20S proteolytic core complex with 19S regulatory subunits. These recognize ubiquitinated proteins and facilitate unfolding and translocation into the 20S lumen.
Defects in this pathway are associated with genetic diseases such as cystic fibrosis, Angelman’s syndrome, and Liddle syndrome.

Usage Note

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.