Thermo Fisher Scientific CRMP1 Polyclonal Antibody, Biotin
CRMP1 단백질을 인식하는 Biotin 결합 토끼 다클론 항체. Western blot, ELISA, IP에 적합. 인간과 생쥐 시료 반응성. Affinity chromatography로 정제되었으며, -20°C에서 보관. 신경세포 분화 및 생존 연구에 활용 가능.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 80–130 of CRMP1 protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Collapsin-response mediator proteins (CRMPs) are highly expressed in the developing brain, where they play major roles in axonal outgrowth, neurite differentiation, and apoptosis. Their continued expression in areas of high synaptic remodeling, such as the cerebellum, hippocampus, and olfactory system, suggests involvement in adult brain plasticity.
CRMP-1 was initially identified as a dihydro-pyrimidinase expressed exclusively in the brain. It is involved in neurotrophin (NT) 3-induced neurite formation and outgrowth. The localization of CRMP-1 shifts from axonal to somatodendritic regions when neurons reach functional maturity, indicating roles in both early neuronal differentiation and later processes related to neuronal survival or death.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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