Thermo Fisher Scientific Cyclophilin A Monoclonal Antibody (ZC001)
Cyclophilin A 단백질을 인식하는 마우스 단클론 항체로 Western blot, IHC, ELISA에 사용 가능. 인간 및 생쥐 시료에 반응하며 비결합형 액상 형태로 제공. 연구용으로 면역억제 관련 단백질 연구에 적합.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:250 | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| ELISA | Assay-dependent | View publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ZC001 |
| Immunogen | Recombinant protein containing the N-terminal region of human cyclophilin A |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Tissue culture supernatant |
| Contains | 0.1% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2533398 |
Target Information
Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents — cyclosporin A (CsA) or FK506. Proteins that bind FK506 are termed FK506 Binding Proteins (FKBPs), and those that bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes inhibit calcineurin, a calcium- and calmodulin-dependent protein phosphatase involved in T-cell activation, providing a mechanism for immunosuppression by CsA and FK506.
Immunophilins function as peptidyl prolyl cis-trans isomerases (PPIase), accelerating protein folding by catalyzing rearrangements of proline-containing proteins. Within the cyclophilin family, several homologous proteins exist, including CyPA, CyPB, and CyPC. CyPA (also known as CyP-18) is the most abundant and ubiquitous cyclophilin found in all vertebrate tissues and is present in T-cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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