Thermo Fisher Scientific SLC1A6 Polyclonal Antibody

Applications and Tested Dilution

Product Specifications

Product Specific Information

• Reconstitute in 100 µL of sterile water.
• Centrifuge to remove any insoluble material.
• Specificity: EAAT4.

Target Information

SLC1A6 (Excitatory Amino Acid Transporter 4, EAAT4)
SLC1A6 encodes a sodium- and potassium-dependent glutamate transporter, belonging to the solute carrier family 1 (SLC1). EAATs are widely distributed throughout the brain, with five known subtypes, each exhibiting distinct distribution patterns.

This transporter mediates uptake of L-glutamate, L-aspartate, and D-aspartate. It functions as a symporter, co-transporting amino acids with Na⁺ and H⁺ ions, while counter-transporting K⁺ ions. SLC1A6 also facilitates Cl⁻ flux to prevent negative charge accumulation from aspartate and Na⁺ symport. It plays a crucial role in clearing glutamate from the synaptic cleft, terminating postsynaptic signaling.

Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.