Thermo Fisher Scientific SLC1A6 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SLC1A6 (EAAT4) for WB and IHC applications. Recognizes extracellular domain peptide of EAAT4. Lyophilized form, reconstitutable in sterile water. Suitable for neuroscience and transporter-related research.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous (PubMed) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from the extracellular domain of human Excitatory Amino Acid Transporter 4 (EAAT4, SLC1A6) conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: EAAT4.
Target Information
SLC1A6 (Excitatory Amino Acid Transporter 4, EAAT4)
SLC1A6 encodes a sodium- and potassium-dependent glutamate transporter, belonging to the solute carrier family 1 (SLC1). EAATs are widely distributed throughout the brain, with five known subtypes, each exhibiting distinct distribution patterns.
This transporter mediates uptake of L-glutamate, L-aspartate, and D-aspartate. It functions as a symporter, co-transporting amino acids with Na⁺ and H⁺ ions, while counter-transporting K⁺ ions. SLC1A6 also facilitates Cl⁻ flux to prevent negative charge accumulation from aspartate and Na⁺ symport. It plays a crucial role in clearing glutamate from the synaptic cleft, terminating postsynaptic signaling.
Diseases associated with SLC1A6 include Dicarboxylic Aminoaciduria.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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