Thermo Fisher Scientific TMEM59 Polyclonal Antibody
TMEM59 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot 및 IHC(P) 실험에 적합합니다. 인간, 마우스, 랫트에 반응하며 항원 친화 크로마토그래피로 정제되었습니다. 알츠하이머병 관련 단백질 연구에 활용 가능합니다.
- 카탈로그번호
- PA521575
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to amino acids 16–311 of TMEM59 (Uniprot ID: Q9BXS4) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_11154807 |
Product Specific Information
- Recommended positive controls: A431, mouse liver, rat kidney
- Predicted reactivity: Mouse (95%), Rat (94%), Pig (96%), Chicken (83%), Rhesus Monkey (98%), Chimpanzee (100%), Bovine (96%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
Processing of the amyloid precursor protein (APP) by alpha- and beta-secretases is a central regulatory event in amyloid beta peptide (Abeta) generation, which plays a key role in Alzheimer’s disease pathogenesis.
TMEM59, a Golgi-localized protein, modulates O-glycosylation and complex N-glycosylation during Golgi maturation of several proteins such as APP, BACE1, SEAP, and PRNP. It inhibits APP transport and shedding.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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