Thermo Fisher Scientific FPGS Recombinant Rabbit Monoclonal Antibody (30C11)
Human FPGS 단백질을 인식하는 Recombinant Rabbit Monoclonal Antibody. Flow Cytometry와 ELISA에 사용 가능. HEK293 세포에서 발현된 고순도 항체로, PBS/glycerol buffer에 보관. 연구용으로만 사용.
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Applications
- Flow Cytometry (Flow): 1:50–1:200
- ELISA (ELISA): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 30C11 |
| Immunogen | A synthesized peptide derived from Human FPGS |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.4 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Wet ice |
| RRID | AB_3092595 |
Target Information
Folylpoly-gamma-glutamate synthetase (FPGS) catalyzes the addition of several equivalents of glutamic acid to the gamma-carboxyl group in the side chain of folate cofactors and analogs.
FPGS has three major functions in mammalian folate homeostasis:
- Polyglutamation prevents efflux of folate cofactors from the cell.
- It increases binding of folate cofactors to enzymes involved in folate interconversion and biosynthesis.
- It enables accumulation of folates in mitochondria required for glycine synthesis.
FPGS is widely expressed in human tumors and is associated with cell proliferation or lack of differentiation. Its function enhances the efficiency of folate antimetabolites by maintaining inhibition of target enzymes over multiple cell generations.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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