Thermo Fisher Scientific tPA Polyclonal Antibody
Human tPA 인식용 Rabbit Polyclonal Antibody로 Western blot 및 IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공. PBS 기반 용액 형태로 장기 보관 시 -20°C에서 안정적 유지.
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Applications
Western Blot (WB)
Tested Dilution: –
View 1 publicationImmunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:50–1:200
References
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human tPA. Recombinant protein control fragment (Product #RP-101047). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2648837 |
Product Specific Information
Immunogen sequence:
KYSSEFCSTP ACSEGNSDCY FGNGSAYRGT HSLTESGASC LPWNSMILIG KVYTAQNPSA QALGLGKHNY CRNPDGDAKP WCHVLKNRRL TWEYCDVPSC STCGLRQYSQ PQFRIKGGLF
Highest antigen sequence identity to orthologs:
- Mouse: 74%
- Rat: 77%
Target Information
TPA converts plasminogen to plasmin by hydrolyzing a single Arg-Val bond. It plays a key role in tissue remodeling, degradation, and cell migration. TPA binds to fibrin, heparin, laminin, and fibronectin, enhancing catalytic efficiency and plasminogen activation. It also interacts with mannose receptor, LRP1, annexin II, and cytokeratin 8, contributing to clearance and regulation of plasminogen activation.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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