Thermo Fisher Scientific IVNS1ABP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.04-0.4 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Immunocytochemistry (ICC/IF)

0.25-2 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human IVNS1ABP. Recombinant protein control fragment (Product #RP-102250). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:IVNS1ABP,uniProtId:Q9Y6Y0-1,ncbiNodeId:9606,antigenRange:343-472,antigenLength:642,antigenImageFileName:PA5-51926_IVNS1ABP_Q9Y6Y0-1_Rabbit.svg,antigenImageFileNamePDP:PA5-51926_IVNS1ABP_Q9Y6Y0-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.2 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2642834

Product Specific Information

Immunogen sequence: QDELIEKPMS PMQYARSGLG TAEMNGKLIA AGGYNREECL RTVECYNPHT DHWSFLAPMR TPRARFQMAV LMGQLYVVGG SNGHSDDLSC GEMYDSNIDD WIPVPELRTN RCNAGVCALN GKLYIVGGSD

Highest antigen sequence identity to the following orthologs: Mouse - 96%, Rat - 95%.

Target Information

IVNS1ABP is a protein coding gene involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro).; (Microbial infection) involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.