Thermo Fisher Scientific SPRYD2 Polyclonal Antibody
SPRYD2 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. WB와 IHC에 적합하며, 인간·마우스·랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 항체로, 근육 관련 단백질 연구에 사용.
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Thermo Fisher Scientific SPRYD2 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | An 18 amino acid peptide near the carboxy terminus of human SPRYD2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at –20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11153374 |
Product Specific Information
- Suggested positive control: Mouse heart tissue lysate
- PA5-21170 can be used with blocking peptide PEP-1284
Target Information
SPRYD2 (also known as Myospryn) was originally identified as the muscle-specific partner of dysbindin and as a Mef-2 target gene.
It is a large scaffolding protein localized to the Z-disc/costamere region of striated muscle.
SPRYD2 includes a noncanonical tripartite motif (TRIM-like) that lacks the RING domain but consists of a B-box coiled coil (BBC), fibronectin 3 (FN3) repeats, and SPRY domains.
SPRYD2 interacts with desmin and calcineurin, and it may play a role in lysosome biogenesis and negatively regulate slow-fiber-type transformation and skeletal muscle regeneration.
SPRYD2 is dysregulated in Duchenne muscular dystrophy.
Usage Notice
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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