Thermo Fisher Scientific CRACC Polyclonal Antibody
Thermo Fisher Scientific의 CRACC Polyclonal Antibody는 인간 CRACC 단백질을 인식하는 토끼 다클론 항체입니다. Western blot과 IHC(P) 검증 완료. 항원 친화 크로마토그래피로 정제되었으며, PBS/glycerol 완충액에 보존됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human CRACC. Recombinant protein control fragment (Product #RP-103238) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2640139 |
Product Specific Information
Immunogen sequence:
ERQEEYIEEK KRVDICRETP NICPHSGENT EYDTIPHTNR TILKEDPANT VYSTVEIPKK MENPHSLLTM P
Highest antigen sequence identity to the following orthologs:
- Mouse: 48%
- Rat: 51%
Target Information
SLAMF7 contains one Ig-like C2-type (immunoglobulin-like) domain.
Isoform 1 mediates NK cell activation through a SAP-independent extracellular signal-regulated ERK-mediated pathway and may play a role in lymphocyte adhesion.
Isoform 3 does not mediate activation. SAP can bind the cytoplasmic tail of isoform 1 when phosphorylated in the presence of Fyn (in vitro).
SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung, and trachea.
Expression was detected in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-, or T-cell lines.
Isoform 3 is expressed at much lower level than isoform 1. There are three named isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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