Thermo Fisher Scientific ABCD4 Polyclonal Antibody
ABCD4 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(Paraffin)에서 검증됨. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제되어 높은 순도 확보. 연구용으로 단백질 발현 및 위치 분석에 적합.
- 카탈로그번호
- PA575480
- 판매단위
- pk
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:1,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 157–202 of Human ABCD4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2719208 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
The peroxisomal membrane contains several ATP-binding cassette (ABC) transporters, ABCD1–4, that are present in the human peroxisome membrane. All four proteins are ABC half-transporters that dimerize to form active transporters.
A mutation in the ABCD1 gene causes X-linked adreno-leukodystrophy (X-ALD), a peroxisomal disorder affecting lipid storage. ABCD2 in mouse is expressed at high levels in the brain and adrenal organs, which are adversely affected in X-ALD.
The peroxisomal membrane also comprises two major proteins, PMP22 and ABCD3. ABCD3 is associated with irregularly shaped vesicles that may represent defective peroxisomes or precursors. ABCD1 localizes to peroxisomes, while ABCB7 is a half-transporter involved in heme transport from mitochondria to the cytosol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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