Thermo Fisher Scientific Bcl-rambo Polyclonal Antibody
인간 BCL2L13 단백질을 인식하는 Rabbit Polyclonal Antibody로, Western blot 및 IHC(PFA)에서 사용 가능. 아폽토시스 연구에 적합하며, 액상 형태로 1 mg/mL 농도. -20°C 보관, Wet ice 배송.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human BCL2L13 (Accession Q9BXK5), corresponding to amino acid residues S208–A258. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2899340 |
Product Specific Information
Antibody detects endogenous levels of total BCL2L13.
Target Information
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in various diseases such as cancer. Members of the Bcl-2 family are critical regulators of apoptosis and contain conserved Bcl-2 homology (BH) domains.
A novel, widely expressed member termed Bcl-rambo has been identified. This protein localizes to mitochondria in mammalian cells, and its overexpression induces apoptosis, which can be blocked by co-expression of inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2. Bcl-rambo shows overall homology to anti-apoptotic Bcl-2 family members but contains a unique 250 amino acid insertion preceding its C-terminal membrane anchor. This region can induce apoptosis more efficiently than the BH domains, suggesting that Bcl-rambo may play an important role in alternative pro-apoptotic pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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