Thermo Fisher Scientific TPMT Monoclonal Antibody (OTI4B1), TrueMAB
TPMT 단백질을 표적으로 하는 마우스 단클론 항체로, Western blot과 IHC(P)에서 검증됨. 인간 시료 반응성, 무보존제, 동결건조 형태. 연구용으로 thiopurine 대사 관련 연구에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:50
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI4B1 |
| Immunogen | Full length human recombinant protein of human TPMT produced in HEK293T cell |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
TPMT catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine.
Defects in TPMT cause thiopurine S-methyltransferase deficiency, affecting drug metabolism.
TPMT activity variations influence patient response and toxicity risks to thiopurine-based immunosuppressive or cytotoxic treatments used in leukemia, autoimmune diseases, and organ transplantation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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