Thermo Fisher Scientific Nurr1 Polyclonal Antibody
Rabbit polyclonal antibody recognizing Nurr1 (NR4A2) protein. Validated for Western blot at 1:500–1:3,000 dilution. Detects mouse, rat, and predicted human, pig, monkey, bovine species. Suitable for dopaminergic system and neurodegenerative disease res...
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Applications
- Western Blot (WB): 1:500–1:3,000
- Positive Control: Mouse brain, Rat brain
- Predicted Reactivity: Human (98%), Pig (98%), Rhesus Monkey (98%), Bovine (98%)
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of mouse Nurr1 (proprietary sequence) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.51 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2736270 |
Product Specific Information
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
The Nuclear receptor related 1 protein (Nurr1), also known as NR4A2 (nuclear receptor subfamily 4, group A, member 2), is encoded by the NR4A2 gene.
Nurr1 is a member of the nuclear receptor family of intracellular transcription factors and plays a key role in maintaining the dopaminergic system of the brain.
Mutations in NR4A2 are associated with disorders involving dopaminergic dysfunction, including Parkinson’s disease, schizophrenia, and manic depression. Misregulation may also be linked to rheumatoid arthritis.
Four transcript variants encoding distinct isoforms have been identified, and additional splice variants may exist but are not fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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