Thermo Fisher Scientific CASC5 Polyclonal Antibody
CASC5 단백질을 검출하기 위한 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF에 적합하며 인간, 마우스, 랫트 반응성. 고순도 Affinity chromatography 정제, PBS+50% glycerol 보존, -20°C 저장.
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Thermo Fisher Scientific CASC5 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human KNL1 (Accession Q8NG31), corresponding to amino acid residues N1621–V1671 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2899579 |
Product Specific Information
Antibody detects endogenous levels of total CASC5.
Target Information
CASC5 performs two crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. It is required for attachment of the kinetochores to the spindle microtubules and directly links BUB1 and BUB1B to kinetochores. CASC5 is part of the MIS12 complex, which may be fundamental for kinetochore formation and proper chromosome segregation during mitosis. It acts in coordination with CENPK to recruit the NDC80 complex to the outer kinetochore.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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