Thermo Fisher Scientific ZRANB2 Monoclonal Antibody (OTI2E3)
인간 ZRANB2 단백질(aa 95-320)을 면역원으로 제작된 Mouse monoclonal antibody. IHC(P)에서 1:2,000 희석 비율로 검증됨. 핵 내 스플라이싱 인자 ZRANB2 검출에 적합. 액상 형태, 1 mg/mL 농도, -20°C 보관.
- 카탈로그번호
- MA527175
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): Tested dilution 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2E3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 95-320 of ZRANB2 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2725738 |
Target Information
Zinc-finger proteins contain DNA-binding domains and perform various transcriptional activation or repression functions.
ZNF265 (also known as ZRANB2, ZIS, ZIS1, or ZIS2) is a 330 amino acid protein belonging to the ZRANB2 family.
Localized to the nucleus, ZNF265 acts as a splicing factor responsible for alternative splicing of Tra-2 beta transcripts and may interfere with constitutive 5′-splice site selection.
It contains two RanBP2-type zinc fingers that mediate RNA-binding activity. Two isoforms (ZIS-1 and ZIS-2) are expressed due to alternative splicing. Upon DNA damage, ZIS-2 may be phosphorylated by ATM or ATR.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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