Thermo Fisher Scientific CD45R (B220) Monoclonal Antibody (YKIX753.22.2)
개 및 면역학 연구용 CD45R(B220) 단일클론 항체로, 다양한 면역분석(IHC, Flow, IP, CT)에 사용 가능. Rat IgG2b 아이소타입, 단백질 G 정제. 1 mg/mL 농도의 액상 제품으로 4°C 또는 -20°C에서 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| Immunoprecipitation (IP) | Assay-dependent |
| Cytotoxicity Assay (CT) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Dog |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | YKIX753.22.2 |
| Immunogen | Canine thymocytes |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745358 |
Available Conjugated Formats
Product Specific Information
This antibody recognizes canine CD45R and was clustered at the First Canine Leucocyte Antigen Workshop (CLAW). It precipitates an antigen of 220 kDa from Con A Blasts.
Target Information
CD45R (PTPRC) is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate cellular processes such as growth, differentiation, mitotic cycle, and oncogenic transformation.
CD45 contains an extracellular domain, a single transmembrane segment, and two tandem intracytoplasmic catalytic domains. It is expressed in hematopoietic cells and regulates T- and B-cell receptor signaling.
CD45 glycoprotein is critical in lymphocyte development and antigen signaling, functioning as a regulator of Src-family kinases. Multiple isoforms exist due to alternative splicing, differing in extracellular domains.
CD45 also modulates integrin-mediated signaling and participates in apoptosis-related DNA fragmentation. CD45RA, an isoform, shows restricted expression among lymphoid cell subtypes.
Dysfunction of CD45 is associated with Severe Combined Immunodeficiency and Hepatitis C.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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