Thermo Fisher Scientific Phospho-Doublecortin (Ser378) Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000

-

Product Specifications

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human Doublecortin (Phospho-Ser378) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Doublecortin,uniProtId:O43602-1,ncbiNodeId:9606,antigenRange:283-308,antigenLength:365,antigenImageFileName:PA5-64493_Doublecortin_O43602-1_Rabbit.svg,antigenImageFileNamePDP:PA5-64493_Doublecortin_O43602-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20°C

Shipping conditions

Wet ice

RRID

AB_2662128

Product Specific Information

Phospho-Doublecortin (Ser378) Polyclonal Antibody detects endogenous levels of Doublecortin only when phosphorylated at Ser378.

Target Information

In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. DCX is a cytoplasmic protein which appears to direct neuronal migration by regulating the organization and stability of microtubules. It contains two doublecortin domains, which bind microtubules. In addition, this protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in the gene encoding DCX are a cause of X-linked lissencephaly.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.