Thermo Fisher Scientific LRP6 Polyclonal Antibody
Human LRP6 단백질을 인식하는 Goat Polyclonal Antibody로, IHC(P) 및 Flow Cytometry에 사용 가능. Wnt/β-catenin 신호전달 연구에 적합하며, 0.5 mg/mL 농도의 액상 형태로 제공. -20°C 보관, 동결/해동 반복 피함.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 4–6 µg/mL |
| Flow Cytometry (Flow) | 10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Goat / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide sequence (CMTSVATAKGYTSDL) corresponding to the internal amino acids of LRP6 (aa 1551–1561) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Ammonium sulfate precipitation |
| Storage Buffer | TBS, pH 7.3, with 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_10983141 |
Product Specific Information
- This antibody is predicted to react with canine, mouse, and rat based on sequence homology.
- Tested in Peptide ELISA: antibody detection limit dilution 64,000.
Target Information
LRP6 is essential for the Wnt/β-catenin signaling pathway, acting as a coreceptor with Frizzled for Wnt. It serves as a specific, high-affinity receptor for DKK1 and DKK2, but not DKK3. Interaction with DKK1 inhibits LRP6-mediated Wnt/β-catenin signaling through Kremen protein-mediated endocytosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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