Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
Caspase-12 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot에 적합하며 ER 스트레스 관련 세포사멸 연구에 활용 가능. 고순도, 액상 형태, -20°C 보관.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Caspase 12 Polyclonal Antibody
Applications
- Western Blot (WB): Tested dilution 1–3 µg/mL
- Refer to publications for detailed usage.
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide (100 GLNIRNKEFNYLHNRNGS 117) of Caspase-12 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2540892 |
Target Information
Three distinct signaling pathways lead to programmed cell death (apoptosis). The death receptor and mitochondrion pathways are the main ones, involving the key apoptotic proteases caspase-8 and caspase-9, respectively.
The endoplasmic reticulum (ER) stress represents the third apoptotic pathway, in which caspase-12 is involved. Caspase-12 is localized to the ER but not to the cytoplasm or mitochondrion. It is activated by ER stress, including disruption of ER calcium homeostasis, and mediates ER stress-induced apoptosis.
Caspase-12 co-localizes with several ER proteins involved in Alzheimer’s disease, including gamma-secretase presenilin and beta-amyloid precursor protein (APP), and mediates cytotoxicity induced by amyloid-beta. Caspase-12 is ubiquitously expressed in mouse tissues.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.